Polycystic Ovary Syndrome and its Association with Insulin Resistance and The Extent of Patients` Awareness Of this Association in the region of Al-khums City, Libya

Polycystic Ovary Syndrome and its Association with Insulin Resistance

الملخص

Polycystic Ovary Syndrome (PCOS) is currently recognized as one of the most common endocrine diseases claimed by women of reproductive age, with a worldwide prevalence ranging from 6 to 21%, depending on the diagnostic criteria, which commonly associated with insulin resistance (IR), (PCOS) syndrome increases the risk of developing type 2 diabetes mellitus. The Method used A cross-sectional study design was used to estimate the association between serum hormones and insulin sensitivity in women with PCOS each participant had their blood drawn following the standard blood draw process. A Mindray CL- 900 i analyzer was used to check the samples and measure the levels of hormones luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin (PRL) and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR). Blood samples were taken from several laboratories in Al-Khums city, Libya, from November 2024 to February 2025. Statistical analysis was performed using IBM SPSS Statistics 23 software to evaluate correlations between hormonal levels and insulin resistance, as well as to compare differences in hormonal profiles across various subgroups.41 women with a diagnosis of Polycystic Ovary Syndrome (PCOS) were included in the study. The mean age of the subjects surveyed was 32.46 years. Spearman correlation coefficients were used to assess the relationship between hormonal levels and insulin resistance. T-tests were employed to compare hormonal levels in patients with high and low insulin resistance. Additionally, a one-way ANOVA was conducted to evaluate differences in insulin resistance across age groups. the study employed questionnaire to assess the awareness or knowledge of (PCOS) patients regarding the association of insulin resistance with this disease. The Result is This study looked at the association of dysfunctional hormones (LH, FSH, and Prolactin) and insulin resistance, along with the knowledge of associated insulin resistance in PCOS. The results demonstrate that there is a high prevalence of insulin resistance in the study sample; however, there were no statistically significant associations between insulin resistance as measured by HOMA-IR and the selected hormonal levels. This indicates that, at least in this population, insulin resistance may be driven by other factors not considered in this study. Furthermore, the study showed the level of awareness towards the association of PCOS and insulin resistance was low, which points to the necessity for tailored educational programs.